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Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: Mesenchymal stem cells combined with autocrosslinked hyaluronic acid improve mouse ovarian function by activating the PI3K-AKT pathway in a paracrine manner

Fig. 6

MSC/HA transplantation mitigated age-related fertility impairment in mice. a Western blot showing the expression of p-AKT and p-rpS6 in the ovaries of young, aged, and aged + MSC/HA mice 4 days after transplantation. b Western blot and c H&E staining showing germ cell marker DDX4 expression and follicle preservation at 8 weeks after transplantation in the three groups. Scale bars = 200 μm. d The numbers of total follicles and e follicles at various stages were counted and compared in the three groups 8 weeks after transplantation (n = 5 for each group). *P < 0.05. PrF, primordial follicle; PF, primary follicle; SF, secondary follicle; AF, antral follicle. f, g Comparison of the average number of litters and number of pups per litter between aged mice and MSC/HA-treated aged mice (n = 7 or 8 for each group). *P < 0.05

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Stem Cell Research & Therapy

ISSN: 1757-6512