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Table 1 Characteristics of the included studies

From: Mesenchymal stem cells-derived therapies for subarachnoid hemorrhage in preclinical rodent models: a meta-analysis

References

Animal, sex

Anesthetic

Method of SAH

MSCs source

Type of MSCs derived therapy

Time of administration

Tre(n)/con(n)

Assessment time

Outcome measure

Chen [21]

SD rat, male

Pentobarbital, IP

Autogenous blood

Human UC-MSCs

UC-MSCs, 2 × 105, ICV

− 1, 10 days post SAH

16/16

21 days

Garcia score and beam balance test (higher is better)

Gao [22]

SD rat, male

Chloral hydrate, IP

Endovascular perforation

BM-MSCs

BM-MSCs-derived EVs, 100 ug, IV

1 h post SAH

12/12; 6/6

48 h

Garcia score (higher is better); BWC (lower is better)

Han [12]

SD rat, male

Isoflurane, inhalation

Endovascular perforation

Rat BM-MSCs

BM-MSCs-derived EVs, 100 ug/500 ul, IV

10 min post SAH

5/5; 5/5

48 h

Garcia score (higher is better); BWC (lower is better)

Lai [14]

C57BL/6 mice, male

Chloral hydrate, IP

Autogenous blood

Mice BM-MSCs

BM-MSCs-derived EVs, IV

22 h post SAH

18/18; 6/6

24 h

Garcia score (higher is better); BWC (lower is better)

Liu [23]

SD rat, male

Pentobarbital, IP

Endovascular perforation

Rat BM-MSCs

BM-MSCs, 3 × 106, IV

1 h post SAH

12/12; 6/6

72 h

Garcia score (higher is better); BWC (lower is better)

Liu [24]

SD rat, NR

NR

Autogenous blood

Human UC-MSCs

UC-MSCs-derived EVs, 100 ug/ml, IV

NR

6/6; 6/6

24 h

Behavior score (lower is better); BWC (lower is better)

Nijboer [13]

Wistar rat, male

Isoflurane, inhalation

Endovascular perforation

SD rat BM-MSCs

BM-MSCs, 1.5 × 106, IN

6 days post SAH

13/10

21 days

Adhesive removal task (lower is better)

Xiong [25]

SD rat, male

Isoflurane, inhalation

Endovascular perforation

Rat BM-MSCs

BM-MSCs-derived EVs, 200 ug/200 ul, IV

1 h post SAH

5/5; 5/5

24 h

Garcia score (higher is better); BWC (lower is better)

Zhao [26]

SD rat, male

Pentobarbital, IP

Autogenous blood

Human UC-MSC

UC-MSCs-derived EVs, 400 ug/200 ul, IV

1 h post SAH

5/5; 5/5

24 h

Garcia score (higher is better); BWC (lower is better)

  1. SAH subarachnoid hemorrhage, MSCs mesenchymal stem cells, Tre treatment, Con control, IP intraperitoneal, NR not recorded, UC-MSCs umbilical cord mesenchymal stem cells, BM-MSCs bone marrow mesenchymal stem cells, EVs extracellular vesicles, ICV intracerebroventricular, IV intravenous, IN intranasal, BWC brain water content