Fig. 2

LINC01119 expression is downregulated during the osteogenic differentiation process of BMSCs. A Heat map of the top 100 DEGs at the differentiation time of 12 h, 1 d, 2 d or 3 d with that at 0 h. Red indicates higher expression, and blue indicates lower expression. B Volcano plot of DEGs at the differentiation time of 3 d with that at 0 h. Genes with significantly different expression are represented by red dots (upregulated) and blue dots (downregulated). Genes without significantly different expression are represented by gray dots. C Box plot of LINC01119 expression at differentiation time of 12 h, 1 d, 2 d or 3 d with that at 0 h. D qRT-PCR analysis for LINC01119 in osteogenic differentiation of BMSCs. E RNA-FISH results for LINC01119 in control group and osteogenic group