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Fig. 9 | Stem Cell Research & Therapy

Fig. 9

From: LINC01119 negatively regulates osteogenic differentiation of mesenchymal stem cells via the Wnt pathway by targeting FZD4

Fig. 9

EBF3 was the transcription factor of LINC01119. A The potential transcription factors for LINC01119 were predicted in UCSC data, and the top four transcription factors were KLF9, KLF4, SOX2 and EBF3. B The potential transcription factors predicted by Lisa database was EBF3. C Motif diagrams of EBF3 predicted by Jaspar database. D, E Chromatin immunoprecipitation (ChIP) assay for EBF3 and LINC01119, the result demonstrated EBF3 directly regulates LINC01119 expression, knockdown of EBF3 supressed the binding of ENF3 and LINC01119, and the band became unconspicuous

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Stem Cell Research & Therapy

ISSN: 1757-6512