Fig. 4
MSCCCR2 possess an increased capacity to home to liver lesions in ALF mice in vivo. A In vivo near-infrared fluorescence imaging of the MSCvector group (right) and MSCCCR2 group (left) at 6 h, 9 h, 12 h, 24 h, 48 h, 72 h, 96 h, and 7 d after transplantation. The fluorescence signal of the PBS group served as the negative control. B Quantitative analysis of the fluorescence signal intensity of the liver region. n = 5 per group. C Ex vivo near-infrared fluorescence imaging of the heart, lungs, liver, spleen, and kidneys in the MSCvector group and MSCCCR2 group at 24 h, 48 h, 96 h, and 7 d after transplantation. The fluorescence signal before transplantation (0 h) served as the negative control. D The line chart shows the changes in the fluorescence signal intensity of heart, lungs, liver, spleen, and kidneys over time. n = 5 per group. E Quantitative analysis of the fluorescence signal intensities of the lungs and liver. n = 5 per group. All data are presented as the mean ± SD. *p < 0.05, **p < 0.01, ***p < 0.001, and n.s. means nonsignificant