Fig. 5
MSCCCR2 infusion improves survival and alleviates liver injury in ALF mice. A Survival analysis of each group. n = 24 per group. ALF + MSCvector group versus ALF + PBS group, p < 0.05; ALF + MSCCCR2 group versus ALF + MSCvector group, p < 0.05. B The serum levels of ALT, AST, and TBIL in each group at 0 h, 12 h, 24 h, 36 h, 60 h, 84 h, and 180 h after TAA injection. n = 5 per group. C Representative photographs and H&E staining images of liver samples from each group collected at 60 h after TAA injection. Scale bar: 100 µm. D Quantification of necrotic area fraction was conducted with five random fields (100 ×) for each liver tissue section. n = 5 per group. E Suzuki's injury score was used as a criterion to assess the severity of liver injury. n = 5 per group. All data are presented as the mean ± SD. *p < 0.05, **p < 0.01, ***p < 0.001, and n.s. means nonsignificant