Fig. 6

Liver β-catenin deficiency inhibited the therapeutic efficacy of MenSC transplantation in DDC-induced models. A Representative images of sections from the control and AAV-infected livers. Scale bar, 50 μm. B Expression levels of β-catenin in liver tissues of AAV-shControl and AAV-shCtnnb1 mice (n = 3 for each group). C Serum AST, ALT, ALP, DBIL and TBIL levels of AAV-shControl and AAV-shCtnnb1 mice in different groups (n = 6 for each group). D, E Representative images of H&E and Masson staining of liver tissues from AAV-shControl and AAV-shCtnnb1 mice in different groups. Scale bar, 250 μm. F Fibrosis area analysis (n = 5 for each group). *p < 0.05, **p < 0.01, ****p < 0.0001 and n.s. indicates no significance between the two indicated groups