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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: Osteogenic differentiation of mesenchymal stem cells promotes c-Jun-dependent secretion of interleukin 8 and mediates the migration and differentiation of CD4+ T cells

Fig. 3

Osteogenic differentiation of MSCs has no effect on the ratio of Th1 to Th2 cells. Flow cytometry was used to assess Th1 and Th2 cells in coculture systems. a, c The differentiation of Th1 cells was inhibited. b, d Th2 cells were slightly increased when CD4+ T cells were cocultured with MSCs. e The ratio of Th1 to Th2 cells showed no difference between the osteogenic group and the control group. f qRT-PCR analysis results showed that the mRNA level of IFN-γ decreased when CD4+ T cells were cocultured with MSCs. h Differences in Th2 cells among the MSC groups were not statistically significant. g, i ELISA showed a similar result. Values are presented as the mean ± SD of 12 samples per group. ns indicated P > 0.05, and * indicates P < 0.05

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