Fig. 3

Transplantation of exosomes and the combinatorially pretreated MSCs reduced infarct size and ameliorated fibrosis after AMI. Representative Masson trichrome staining images (A) and quantitative analysis (B) of infarct size at 4 weeks post-AMI (n = 7), Scale bar = 2000 μm. Representative Sirius red staining images (C) and quantification (D) of the collagen area at 4 weeks post-AMI (n = 7), Scale bar = 2000 μm. Data are presented as mean ± SEM and were analyzed by one-way ANOVA followed by Tukey’s test. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001 versus AMI group; ^$p < 0.05, ^$$p < 0.01, ^$$$p < 0.001, ^$$$$p < 0.0001 versus Exo group; ^&p < 0.05, ^&&p < 0.01, ^&&&p < 0.001, ^&&&&p < 0.0001 versus MSC group; ^#p < 0.05 versus Exo + MSC group; ^αp < 0.05 versus Exo + MSC^H group; ^μp < 0.05 versus Exo + MSC^T group