Skip to main content
Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: CRISPR single base editing, neuronal disease modelling and functional genomics for genetic variant analysis: pipeline validation using Kleefstra syndrome EHMT1 haploinsufficiency

Fig. 4

Genes showing differences in expression during differentiation for EHMT1_SNV compared to EHMT1_WT reveal predominant REST and SP1 modulation. Heatmap of normalised log2 counts per million, where genes have been centred and scaled by the standard deviation for the 109 genes showing differences in expression during differentiation for EHMT1_SNV compared to EHMT1_WT. Genes with REST and SP1 motifs are highlighted. List of genes that were identified with REST motif (green highlight) or in REST gene sets (pale orange highlight), and with SP1 motif (purple highlight)

Back to article page

Stem Cell Research & Therapy

ISSN: 1757-6512