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Fig. 8 | Stem Cell Research & Therapy

Fig. 8

From: Melatonin enhances osteogenic differentiation of dental pulp mesenchymal stem cells by regulating MAPK pathways and promotes the efficiency of bone regeneration in calvarial bone defects

Fig. 8

Effects of MAPK pathway inhibitors on osteogenic differentiation of DPSCs treated with 100 μM melatonin at 7 and 14 days after incubation with osteogenic differentiation medium. a, b SB203580 (p38 MAPK inhibitor) and PD98059 (ERK MAPK inhibitor) significantly reduced the mineral matrix depositions of 100 μM melatonin-treated DPSCs. c The gene expression of ALP, BMP-2, OCN, and RUNX2 in 100 μM melatonin-treated DPSCs was suppressed in the experimental groups with SB203580 and PD98059 inhibitors. Scale bar = 100 μm. (*p < 0.05, **p < 0.01)

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Stem Cell Research & Therapy

ISSN: 1757-6512