Table 3 The application of BMSCs in vivo
From: Application of stem cells in the repair of intervertebral disc degeneration
Year | Team | Source of stem cells | Model | Observation time | Results |
|---|---|---|---|---|---|
2006 | Sakai et al. [50] | Rabbit BMSCs | Rabbit IDD model | 24 weeks | IVD cells↑, cell survival rate↑, proteoglycan content↑ |
2014 | Yi et al. [54] | Transgenic rabbit BMSCs | Rabbit IDD model | 12 weeks | IVD degeneration↓, ECM↑, hTIMP-1 mRNA and protein expression levels↑ |
2018 | Teixeira et al. [35] | Human BMSCs | Bovine IDD model | 16 days | BMSCs migrate directionally, the expression of IL-6,IL-8,TNF-α ↓ by paracrine stimulation |
2019 | Hussain et al. [51] | Allogeneic sheep BMSCs + acellular high-density collagen gel | Sheep IDD model | 6 weeks | DHI, Pfirrmann grade, NP area all perform well, AF and NP tissue improve in histology |
2019 | Shi et al. [55] | Neonatal dermal fibroblasts + rabbit dermal fibroblasts | Rabbit IDD model | 8 weeks | IVD can tolerate transplantation of allogeneic or xenogeneic cells |
2020 | Yan et al. [52] | Rabbit BMSCs + salvianolic acid B | Rabbit IDD model | 8 weeks | Salvianolic acid B can improve the repair effect of BMSCs |
2020 | Lykov et al. [53] | Rat BMSCs + EPO | Rat IDD model | 21 days | IVD height↑, NP content change, EPO can inhibit the migration of MSCs to prevent IVD repair |