Table 4 The application of ADMSCs in vitro
From: Application of stem cells in the repair of intervertebral disc degeneration
Year | Team | Source of stem cells | Results |
|---|---|---|---|
2008 | Lu et al. [68] | Human ADMSCs + NP cells | COL II content↑, ACAN gene expression ↑ |
2013 | Jin et al. [66] | Rat ADMSCs + TGF-β3 | IVD cells↑, ECM↑ |
2014 | Clarke et al. [67] | Human ADMSCs + TGF-β1, GDF-5, GDF-6 | COL II, glycosaminoglycan content↑, ECM↑,ability of ADMSCs differentiating into NP cells↑ |
2015 | Sun et al. [71] | Human ADMSCs | ECM↑, TIMP expression↑, inhibit caspase-3, caspase-9 |
2018 | Han et al. [70] | Human ADMSCs + degenerative NP cells | lnc RNA and mRNA express differentially |
2021 | Dai et al. [69] | Rat BMSCs/ADMSCs | ADMSCs perform better in NP cells markers genes and chondrocyte-specific genes expression than BMSCs |
2021 | Han et al. [72] | Human ADMSCs + degenerative NP cells | Express 360 lncRNA and 1757 mRNA differentially, 589 genes expression↑, 661 expression↓, 299 signaling pathway change |