From: Application of stem cells in the repair of intervertebral disc degeneration
Year | Team | Source of stem cells | Model | Observation time | Results |
---|---|---|---|---|---|
2009 | Ganey et al. [73] | Canine ADMSCs + HA | Canine IDD model | 12 months | COL II, proteoglycan content ↑, cell density↑ |
2014 | Marfia et al. [64] | Human ADMSCs | Rat IDD model | 12 weeks | Biglycan content↑, ACAN gene expression↑, imaging signals in IVD↑ |
2018 | Zhou et al. [74] | Human ADMSCs + pig acellular NP scaffold | Rabbit IDD model | 16 weeks | ECM↑, the mechanical properties and biocompatibility of the combination system are brilliant, ADMSCs differentiate into NP cells |
2019 | Ishiguro et al. [75] | Transgenic rat ADMSCs | Rat IDD model without NP | 6Â months | Biomechanical properties are maintained in 6Â weeks, IVD height maintain, AF and CEPs retain in 6Â months |
2019 | Hua et al. [76] | Pretreated human ADMSCs | Rat tail IDD model | 16 weeks | NP-specific markers genes expression and ECM↑, IVD height, water content and ECM content all change |