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Table 5 The application of ADMSCs in vivo

From: Application of stem cells in the repair of intervertebral disc degeneration

Year

Team

Source of stem cells

Model

Observation time

Results

2009

Ganey et al. [73]

Canine ADMSCs + HA

Canine IDD model

12 months

COL II, proteoglycan content ↑, cell density↑

2014

Marfia et al. [64]

Human ADMSCs

Rat IDD model

12 weeks

Biglycan content↑, ACAN gene expression↑, imaging signals in IVD↑

2018

Zhou et al. [74]

Human ADMSCs + pig acellular NP scaffold

Rabbit IDD model

16 weeks

ECM↑, the mechanical properties and biocompatibility of the combination system are brilliant, ADMSCs differentiate into NP cells

2019

Ishiguro et al. [75]

Transgenic rat ADMSCs

Rat IDD model without NP

6 months

Biomechanical properties are maintained in 6 weeks, IVD height maintain, AF and CEPs retain in 6 months

2019

Hua et al. [76]

Pretreated human ADMSCs

Rat tail IDD model

16 weeks

NP-specific markers genes expression and ECM↑, IVD height, water content and ECM content all change

  1. ADMSCs adipose mesenchymal stem cells, ACAN aggrecan, AF annulus fibrosus, CEPs cartilaginous endplates, COL II collagen type II, ECM extracellular matrix, HA hyaluronic acid, IDD intervertebral disc degeneration, IVD intervertebral disc, NP nucleus pulposus