Table 6 The application of WJMSCs, IVDSCs and PSCs in vitro
From: Application of stem cells in the repair of intervertebral disc degeneration
Year | Team | Source of stem cells | Results |
|---|---|---|---|
2016 | Wang et al. [81] | Human WJMSCs | WJMSCs genes expression pattern is similar to ADMSCs, inflammatory stimulation can regulate genes expression |
2018 | Beeravolu et al. [82] | Induce human WJMSCs differentiating into CPCs | Cell structure change, glycosaminoglycan content and ECM↑ |
2019 | Qi et al. [83] | Human WJMSCs | Activate MAPK signaling pathway, promote B-cell lymphoma-2 expression and inhibit Bax expression, ECM↑and ECM degradation ↓, COL II and proteoglycan content↑, regulate mitosis and apoptosis |
2020 | Zhao et al. [84] | Human WJMSCs + human NP cells | Reverse the apoptotic ratio of NP cells, block Wnt/β-catenin pathway to inhibit Wnt-related genes expression |
2013 | Barreto et al. [85] | Rabbit NPSCs | NPSCs migrate along the fibers and cells in IVD |
2016 | Wang et al. [86] | BMSCs/NPSCs/AFSCs/CESCs | CESCs are stronger in osteogenesis and chondrogenesis than the other three |
2017 | Huang et al. [87] | NPSCs | Hypoxia can promote NPSCs proliferation related to HIF-1α signaling pathway, Simvastatin can promote NPSCs transfer into NP cells |
2018 | He et al. [88] | Human CESCs | Promote CEPs repair, promote NP cells proliferation |
2015 | Liu et al. [89] | Human IPSCs + pig NP cell ECM | NP cells secret regulatory factors, mediate the differentiation of IPSCs into NP cells |
2020 | Hu et al. [90] | GDF-5 transfected human IPSCs + rat NP cells | Chondrocyte markers genes expression↑ |