Table 7 The application of WJMSCs, IVDSCs and PSCs in vivo
From: Application of stem cells in the repair of intervertebral disc degeneration
Year | Team | Source of stem cells | Model | Observation time | Results |
|---|---|---|---|---|---|
2018 | Beeravolu et al. [82] | WJMSCs differentiate into CPCs | Rabbit IDD model | 8Â weeks | NP-specific markers genes express more significantly in CPCs group |
2020 | McKee et al. [91] | Human WJMSCs + degenerative rabbit NP cells + scaffold | Rabbit IDD model | 8 weeks | Promote WJMSCs differentiating into NP cells, avoid cell leakage and complications |
2016 | Chen et al. [92] | Human NPSCs/NP cells | Rabbit IDD model | 8Â weeks | NPSCs have better IVD repair effect than NP cells |
2021 | Marimuthu et al. [93] | Rat NPSCs | Allogeneic rat IDD model | 21 days | NPSCs regenerative ability is stronger, MSCs anabolic activity↑and catabolic activity ↓, allotransplantation cause pro-inflammatory effect stronger |
2009 | Sheikh et al. [94] | Rat ESCs | Rabbit IDD model | 8Â weeks | Generate NCs |
2020 | Hu et al. [90] | Transfected human IPSCs + GDF-5 hydrogel | Rat IDD model | 3 months | IDD symptoms improve both in imaging and histology |
2021 | Sun et al. [95] | Transfect human IPSCs to IMSCs | Rat IDD model | 8Â weeks | NP cells senescence delay, and restore the age-related function, activate SIRT6 pathway, downregulate PDE4D level |