From: Application of stem cells in the repair of intervertebral disc degeneration
Year | Team | Source of stem cells and vectors | Model | Results |
---|---|---|---|---|
2016 | Gan et al. [105] | Glucose-gelatin hydrogel scaffold-loaded TGF-β3 + mouse BMSCs | In vitro | BMSCs differentiate into NP cells, ECM gene expression↑ |
2016 | Wu et al. [107] | Self-assembled peptide nanofiber scaffold + rabbit BMSCs + rabbit chondrocytes | Rabbit IDD model | Promote BMSCs differentiating into NP cells, promote BMSCs proliferation and chemotactic migration |
2018 | Zhang et al. [106] | Microencapsulated rabbit chondrocytes + rabbit BMSCs | Rabbit IDD model | The combination system do not affect the function of BMSCs, COL II and proteoglycan content↑, the repair effect of co-culture group perform better than the original BMSCs group |
2018 | Zhang et al. [110] | Albumin/heparin nanoparticles loaded with SDF-1α | Rabbit IDD model | Induce IVD regeneration, enhance the homing ability of BMSCs |
2018 | Zhou et al. [74] | Human ADMSCs loaded in pig acellular NP scaffolds | Rabbit IDD model | ECM↑, the mechanical properties and biocompatibility of the combination system are brilliant, ADMSCs differentiate into NP cells |
2019 | Hussain et al. [51] | Allogeneic sheep BMSCs loaded in acellular high-density collagen gel | Sheep IDD model with AF injured | DHI, Pfirrmann grade, NP area all perform well in 6Â weeks, AF and NP tissue improve in histology |
2019 | Naqvi et al. [104] | Pig BMSCs embedded in alginate microcapsules | Bovine IVD model | ECM↑ |
2019 | Ishiguro et al. [75] | Stent-free tissue engineering structure made by ADMSCs | Rat IDD model without NP | Biomechanical properties are maintained, IVD height maintain, AF and CEPs retain |
2020 | Choi et al. [109] | WJMSCs loaded in hyaluronic acid-methylcellulose hydrogel system | Rat IDD model | Improve the viability of NP cells, reduce ECM degradation |
2021 | Kuang et al. [108] | Acellular NP matrix and chitosan hydrogel scaffold + TGF-β3 + NPSCs | In vitro | NPSCs grow better in scaffold group, COL I,COL II and proteoglycan content↑ |