Therapeutic efficacy of mesenchymal stem cells for abdominal aortic aneurysm: a meta-analysis of preclinical studies

Li, Xintong; Wen, Hao; Lv, Junyuan; Luan, Boyang; Meng, Jinze; Gong, Shiqiang; Wen, Jie; Xin, Shijie

doi:10.1186/s13287-022-02755-w

Stem Cell Research & Therapy

Table 1 Characteristics of preclinical studies investigating the therapeutic efficacy of MSCs in AAA models

From: Therapeutic efficacy of mesenchymal stem cells for abdominal aortic aneurysm: a meta-analysis of preclinical studies

Author	Year	Country	No. of MSC group	No. of control group	AAA model	Animal species	MSC source	Cell compatibility	Intervention route	Total dose (cells)	Control	Follow-up duration (days)
Hashizume [28]	2011	Japan	7	6	AngII	apoE^−/− mice	Bone marrow	Allogenic	Perivascular	1*10⁵	NS	28
Sharma [15]	2012	USA	6	8	Elastase	C57BL/6 mice	Placenta	Xenogenic	Intravenous	1*10⁶	NS	14
Fu-1 [27]	2013	Japan	10	5	AngII	apoE^−/− mice	Bone marrow	Allogenic	Intravenous	1*10⁶	Saline	28
Fu-2 [27]	2013	Japan	12	5	AngII	apoE^−/− mice	Bone marrow	Allogenic	Intravenous	4*10⁶	Saline	28
Schneider-1 [32]	2013	France	6	3	Xenograft	Fischer rats	Bone marrow	Allogenic	Intraluminal	1*10⁶	medium	7
Schneider-2 [32]	2013	France	5	3	Xenograft	Fischer rats	Bone marrow	Allogenic	Intraluminal	1*10⁶	medium	28
Blose [21]	2014	USA	7	6	Elastase	C57BL/6 mice	Adipose tissue	Allogenic	Perivascular	1*10⁵	Saline	9
Yamawaki-Ogata-1 [30]	2014	Japan	10	10	AngII	apoE^−/− mice	Bone marrow	Allogenic	Intravenous	1*10⁶	Saline	14
Yamawaki-Ogata-2 [30]	2014	Japan	7	6	AngII	apoE^−/− mice	Bone marrow	Allogenic	Intravenous	1*10⁶	Saline	28
Yamawaki-Ogata-3 [30]	2014	Japan	6	5	AngII	apoE^−/− mice	Bone marrow	Allogenic	Intravenous	1*10⁶	Saline	56
Zidi [33]	2015	France	6	6	Xenograft	Fischer rats	Bone marrow	Allogenic	Intraluminal	1*10⁶	NS	7
Davis-1 [22]	2015	USA	11	4	Elastase	C57BL/6 mice	Bone marrow	Allogenic	Intravenous	9 × 10⁶	NS	14
Davis-2 [22]	2015	USA	9	4	Elastase	C57BL/6 mice	Bone marrow	Allogenic	Intravenous	9 × 10⁶	NS	14
Sharma [23]	2016	USA	8	8	Elastase	C57BL/6 mice	Umbilical cord	Xenogenic	Intravenous	1*10⁶	NS	14
Xie-1 [25]	2017	USA	4	4	Elastase	C57BL/6 mice	Adipose tissue	Xenogenic	Intravenous	1*10⁶	PBS	4
Xie-2 [25]	2017	USA	5	5	Elastase	C57BL/6 mice	Adipose tissue	Xenogenic	Intravenous	1*10⁶	PBS	7
Xie-3 [25]	2017	USA	4	4	Elastase	C57BL/6 mice	Adipose tissue	Xenogenic	Intravenous	1*10⁶	PBS	14
Yamawaki-Ogata [31]	2017	Japan	5	5	AngII	apoE^−/− mice	Bone marrow	Allogenic	Intravenous	1*10⁶	Saline	14
Hosoyama-1 [29]	2018	Japan	24	8	Elastase CaCl2	SCID mice	Bone marrow	Xenogenic	Intravenous	6*10⁴	PBS	7, 14, 21
Hosoyama-2 [29]	2018	Japan	24	8	Elastase CaCl2	SCID mice	Bone marrow	Xenogenic	Intravenous	6*10⁴	PBS	28, 35, 42, 56, 64
Parvizi [36]	2018	Netherlands	6	6	Elastase CaCl2	Fischer rats	Adipose tissue	Allogenic	Perivascular	2*10⁶	NS	14
Spinosa [24]	2018	USA	12	12	Elastase	C57BL/6 mice	Umbilical cord	Xenogenic	Intravenous	1*10⁶	NS	14
Zidi [34]	2018	France	6	6	Xenograft	Fischer rats	Bone marrow	Allogenic	Intraluminal	1*10⁶	NS	7
Zhou [35]	2019	China	8	8	AngII	apoE^−/− mice	Bone marrow	Allogenic	Intravenous	2*10⁶	medium	14
Wen-1 [16]	2020	China	10	5	Elastase	SD rats	Umbilical cord	Xenogenic	Intravenous	1*10⁶	Saline	7
Wen-2 [16]	2020	China	10	5	Elastase	SD rats	Umbilical cord	Xenogenic	Intravenous	1*10⁶	Saline	14
Akita-1 [26]	2021	Japan	10	5	AngII	apoE^−/− mice	Bone marrow	Allogenic	Intravenous	1*10⁶	Saline	14
Akita-2 [26]	2021	Japan	10	5	AngII	apoE^−/− mice	Bone marrow	Allogenic	Intravenous	1*10⁶	Saline	14

MSCs, mesenchymal stem cells; AAA, abdominal aortic aneurysm; AngII, angiotensin II; apoE^−/−, apolipoprotein E knockout mice; PBS, phosphate buffered saline; NS, not mentioned

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ISSN: 1757-6512

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