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Fig. 10 | Stem Cell Research & Therapy

Fig. 10

From: Important role of the SDF-1/CXCR4 axis in the homing of systemically transplanted human amnion-derived mesenchymal stem cells (hAD-MSCs) to ovaries in rats with chemotherapy-induced premature ovarian insufficiency (POI)

Fig. 10

Inhibition of the PI3K/Akt signalling pathway reduces hAD-MSC homing in vivo. a Transplanted PKH26-labelled hAD-MSCs were observed in ovaries at 24 h after cell transplantation in the hAD-MSCs and hAD-MSCs + LY294002 groups using confocal microscopy (×200 and ×800). b The number of hAD-MSCs was counted and compared in the hAD-MSCs and hAD-MSCs + LY294002 groups (n = 10). Representative images are shown. The yellow arrows indicate transplanted hAD-MSCs. *P < 0.05. Scale bars = 100 μm

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Stem Cell Research & Therapy

ISSN: 1757-6512