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Fig. 8 | Stem Cell Research & Therapy

Fig. 8

From: Important role of the SDF-1/CXCR4 axis in the homing of systemically transplanted human amnion-derived mesenchymal stem cells (hAD-MSCs) to ovaries in rats with chemotherapy-induced premature ovarian insufficiency (POI)

Fig. 8

Activation of the PI3K/Akt signalling pathway by SDF-1 in hAD-MSCs. a–c The effects of SDF-1 on the phosphorylation of ERK1/2 and Akt in hAD-MSCs were determined using Western blot analysis (a), and the phospho-ERK1/2/ERK1/2 and phospho-Akt/Akt ratios were evaluated (b, c). d, e Akt and phospho-Akt levels were analysed using Western blotting after pretreatment of hAD-MSCs with AMD3100 or LY294002 for 1 h followed by treatment with SDF-1 (d), and the phospho-Akt/Akt ratios were evaluated (e). *P < 0.05 and **P < 0.01

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Stem Cell Research & Therapy

ISSN: 1757-6512