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Table 5 Liver function tests before and after BMMNCs administration

From: Autologous bone marrow mononuclear cell infusion for liver cirrhosis after the Kasai operation in children with biliary atresia

Indicator Baseline 3 months 6 months 12 months
(N = 19) (N = 19) (N = 18) (N = 18)
Median [min; max] Median [min; max] Median [min; max] Median [min; max]
Serum Bilirubin (mg/dL) 2.5 1.3 0.7 0.4
  [0.9; 7.0] [0.3; 10.4] [0.2; 5.7] [0.2; 4.7]
   P = 0.77 P = 0.02* P = 0.026*
Alanine Aminotransferase (ALT) (U/L) 86.9 87.0 103.5 47.8
  [18.8; 502.0] [10.1; 265.2] [16.6; 276.0] [16.6; 876.0]
   P = 0.74 P = 0.93 P = 0.22
Aspartate Aminotransferase (AST) (U/L) 115.8 107.5 90.9 65.5
  [32.4; 954] [31.4; 224.3] [37.5; 276.5] [37.5; 285]
   P = 0.154 P = 0.79 P = 0.08
Gamma-Glutamyl Transferase (GGT) 211.3 201.3 228.0 149.1
  [18.8; 502.0] [10.1; 265.2] [14.0; 556.5] [14.0; 624.4]
   P = 0.06 P = 0.39 P = 0.005**
International Normalized Ratio (INR) 1.06 1.05 1.03 1.05
  [0.9; 1.42] [0.9; 1.37] [0.8; 1.27] [0.9; 1.26]
   P = 0.18 P = 0.036* P = 0.163
Albumin (g/dL) 3.8 3.9 4.1 3.8
  [2.7; 4.5] [3.3; 4.5] [3.1; 4.4] [3.2; 4.1]
   P = 0.10 P = 0.03* P = 0.72
Prothrombin Time (PT) (second) 11.7 11.6 11.6 11.7
  [9.8; 18.0] [10.4; 15.3] [9.9; 15.4] [10.3; 16.9]
   P = 0.32 P = 0.35 P = 0.61
  1. *P value < 0.05; **P value < 0.01