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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: Exosomes derived from stem cells of human deciduous exfoliated teeth inhibit angiogenesis in vivo and in vitro via the transfer of miR-100-5p and miR-1246

Fig. 4

SHED-Exos inhibit the tube formation of endothelial cells in vivo. A Matrigel tube formation assay showing the inhibitory effect of SHED-Exos on capillary-like structures formed by HUVECs. Scale bars = 300 μm. B Quantification of tube length and number of tube branches in the network structures of HUVECs in A. C Western blot analysis showing the protein expression levels of VEGFA, MMP-9 and ANGPT1. D Quantification of the relative levels of VEGFA, MMP-9 and ANGPT1 in C as relative fold change to the respective control cells. E Matrigel tube formation assay of the PBS group, the CM group, the CM + GW4869 group and the CM + GW4869 + Exo group. Scale bars = 300 μm. F Quantification of tube length and number of branches in the network structures of HUVECs in E. Means and standard deviations are shown in each group in B, E, G and I. *P < 0.05, **P < 0.01, ***P < 0.001

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Stem Cell Research & Therapy

ISSN: 1757-6512