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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: Small extracellular vesicles from dental follicle stem cells provide biochemical cues for periodontal tissue regeneration

Fig. 3

DFSCs-sEVs facilitated osteogenic differentiation of PDLSCs. A Experiment design for osteoinduction. B Alizarin red staining of PDLSCs on day 14 after osteoinduction showed that more mineralized nodules formed in the PDLSCs treated with DFSCs-sEVs. Scale bar = 100 μm. C Expression of osteogenic genes COL1, ALP, RUNX2, and BSP in PDLSCs for 7 and 14 days after osteoinduction. D Expression of osteogenic proteins COL1, ALP, RUNX2, and BSP in PDLSCs for 7 and 14 days after osteoinduction. E Quantitative analysis of protein expression levels. The samples derive from the same experiment and that blots were processed in parallel. Full-length gel images are provided in the supplementary file.n = 3, *p < 0.05; **p < 0.01; ***p < 0.001; #p < 0.0001

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