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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: Human umbilical cord mesenchymal stem cell promotes angiogenesis via integrin β1/ERK1/2/HIF-1α/VEGF-A signaling pathway for off-the-shelf breast tissue engineering

Fig. 3

HUCMSCs transplantation promoted the survival of adipose tissue in fat graft without breast scaffold. A After 12 weeks of implantation, all the tissue was measured and photographed. The retention rates of grafted fat in the Low hUCMSC group and Medium hUCMSC group were significantly higher than that of the Control group (*P < 0.05, **P < 0.001). B HE staining of fat tissue after 12 weeks of implantation (black arrows: fibrosis; stars: cysts or vacuoles; red arrows: blood vessels (scale bars = 200 µm). C Histologic evaluation scores demonstrating that hUCMSCs could inhibit necrosis, fibrosis and improve adipose proportion in grafted tissue. D, E The diameter of adipocytes was measured and classified in different groups, and the low hUCMSC group holds the highest proportion of mature adipocytes among four groups (*P < 0.05, **P < 0.01, ***P < 0.001). F The low hUCMSC group holds the lowest cavitary necrosis area and fibrosis degree, but the highest fat tissue occupation among four groups

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