Fig. 5

HUCMSCs improved angiogenesis and fat proportion in fat graft with breast scaffold. A Scheme of breast tissue engineering construct and the harvested implants. B HUCMSCs significantly improved the volumes and mass of the scaffold compounds after 12 weeks of implantation. C HE staining of scaffold compounds was shown in (Stars: cysts or vacuoles; Scale bars = 200 µm). D HUCMSCs inhibited fibrosis and improved the fat proportion in implants (*P < 0.05, **P < 0.01, ***P < 0.001). E HUCMSCs also significantly decreased the thickness of the fibrous capsule of implants (*P < 0.05, **P < 0.01, ***P < 0.001). F HUCMSCs significantly increased the area of blood vessels (CD31⁺, green fluorescence) in the engineered breast tissue (scale bars = 100 µm). G HUCMSCs significantly decreased the number of macrophages (CD68⁺, green fluorescence, depicted by white triangles) in the implants. (Scale bars = 100 µm)