Fig. 7

Graphical abstract describes that PRL-1 activates PDGF signaling to improve vascular remodeling in ovarian, thereby improving ovarian function. PD-MSCs placenta-derived mesenchymal stem cells, PRL-1 phosphatase of regenerating liver-1, PDGF-BB platelet-derived growth factor-BB, PDGFRβ platelet-derived growth factor receptor beta, VEGF vascular endothelial growth factor, VEGFR2 vascular endothelial growth factor receptor 2, mTOR mammalian target of rapamycin, LC3 microtube-associated protein 1 light chain 3, PKCδ protein kinase C-delta, Src proto-oncogene tyrosine-protein kinase Src, ERG ETS-related gene, FZD4 frizzled class receptor 4, AMH anti-Mullerian hormone, E2 estrogen, Nobox newborn ovary homeobox, BMP15 bone morphogenetic protein 15, EGFR epidermal growth factor receptor