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Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: Adipose-derived stem cells ameliorate atopic dermatitis by suppressing the IL-17 expression of Th17 cells in an ovalbumin-induced mouse model

Fig. 2

ADSCs improve histological features of lesion sites and decrease serum IgE levels in mice with OVA-induced AD. a Representative H&E staining photomicrographs of dorsal skin samples from the four groups. The epidermis and dermis are distinguished by white dotted lines, with the parts above the white dotted line representing the epidermal layer. Scale bar = 100 μm. b Representative TB staining photomicrographs of dorsal skin samples from the four groups. Red arrows show infiltrated mast cells. Scale bar = 100 μm. c Measurement of epidermal thickness in skin samples; n = 10 per group. d Measurement of infiltrated mast cells in skin samples; n = 10 per group. e Serum IgE level on day 50; n = 6 per group. *p < 0.05; ****p < 0.0001. Scale bar = 100 μm. NC, normal control; PBS, phosphate-buffered saline; ADSC, adipose-derived stem cell; COR, cortisone; IgE, immunoglobulin E; AD, atopic dermatitis; OVA, ovalbumin; TB, Toluidine Blue

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