Fig. 2

Treatment with sEV-IL10 dramatically enhanced the therapeutic effect of sEV-N. A Mean clinical scores of mice in single injection group and multiple injection group recorded every 2 d from day 8 to day 22 post-immunization. B Mean clinical scores of mice in single injection group and multiple injection group on day 18 post-immunization. C, D Representative histopathological images and scores in the single injection group and multiple injection group. E Mean clinical scores in the sEV-N-, sEV-IL10-, and sEV-V-treated (50 μg) groups recorded every 2 d from day 8 to day 22 post-immunization. F Mean clinical scores of each sEV-treated group on day 18 post-immunization. G, H Representative histopathological images and scores in the sEV-N-, sEV-IL10-, and sEV-V-treated (50 μg) groups. Mean ± SD, n = 6 per group, one-way ANOVA test. ***P < 0.01, *P < 0.05