Fig. 6
Inhibitory effects of sEVs derived from MSCs on the proliferation of T-cells. A, B sEV-N inhibit the proliferation of CD3/CD28-activated T-cells in a concentration-dependent manner. C, D sEV-IL10 enhance the suppressive effect of sEV-N on the proliferation of CD3/CD28-activated T-cells at concentrations of 10 μg/ml. E. Inhibitory effects of sEVs on antigen-specific T-cell responses. F, G Secreted cytokine levels of IFN-γ and IL17A in 20 μg/ml IRBP651–670-stimulated culture supernatants were determined by ELISA. Mean ± SD, one-way ANOVA test. ***P < 0.01, *P < 0.05