Fig. 8

SNHG5 and GDF5 promote bone formation in the critical calvarial defect of mice. a Reconstructed 3D micro-CT images of bone formation in each group. b, c BV and BV/TV analysis of each group at 5 weeks (n = 5). d H&E staining, Masson’s trichrome staining in each group. Scale bars: 200 μm. (***p < 0.001). BV, bone volume; BV/TV, bone volume/tissue volume; GDF5, growth differentiation factor 5; H&E, hematoxylin and eosin; micro-CT, micro-computed tomography; SNHG5, small nucleolar RNA host gene 5; 3D, three-dimensional