Table 1 Basic characteristics of the included studies
References | Year | Country | Design | Sample size (female/male) | Average age | Follow-up time | Source of MSCs | Cell number of MSCs | Administration method |
|---|---|---|---|---|---|---|---|---|---|
Almadori [22] | 2019 | America | Self-control | 62 (61/1) | 56 | 12.41 ± 8.64 m | ADSCs | NA | IH |
Blezien [23] | 2017 | Italy | Self-control | 7 (7/0) | 46.28 | 1/6/12Â m | ADSCs | NA | IH |
Francesco [24] | 2017 | Italy | Self-control | 6 (4/2) | NA | 3Â m | SVF | NA | IH |
2015 | France | Self-control | 12 (12/0) | 54.5 | 2/6/12/22/30Â m | SVF | NA | IH | |
Keyszer [25] | 2011 | Germany | Self-control | 3 (1/2) | 54.67 | 3/6 m | BMSCs | 0.7–1.8 × 106/kg | IV |
Park [26] | 2020 | Korea | Self-control | 18 (15/3) | NA | 2/6/24w | SVF | 3.61 × 106 | IH |
Scuderi [27] | 2013 | Italy | Self-control | 6 (4/2) | NA | 12 m | ADSCs | 8 × 105/ml of HA | IH |
Wang [28] | 2013 | China | Self-control | 5 (2/3) | 44.6 | 1/3/6/12 m | UC-MSCs | 1 × 106/kg | IV |
Zhang [29] | 2017 | China | Self-control | 14 (11/3) | 37.4 | 1/3/6/12 m | UC-MSCs | 1 × 106/kg | IV |