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Fig. 1 | Stem Cell Research & Therapy

Fig. 1

From: Engineering strategies for customizing extracellular vesicle uptake in a therapeutic context

Fig. 1

Schematic diagram that represents EV engineering for cancer therapy in clinical application. A Activation of immunomodulatory cells (including Treg) and inhibition of cytotoxic cells (including NK cells) by cancer cell EVs in order to suppress immune response and lead to metastasis. B Treatment of cancer cell EV to cease EV uptake by immune cells, in order to activate immune response and inhibit metastasis. C Loading chemotherapy drugs into EV and engineering EV uptake to treat cancers. D Three dimensional image of immunomodulatory cells (Green) and cytotoxic cells (Purple) which are respectively activated and inhibited by EVs (Blue) secreted by cancer cells (Pink)

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