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Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: The therapeutic potential of stem cell-derived exosomes in the ulcerative colitis and colorectal cancer

Fig. 2

The modulatory effect of MSC-Exo on the dysregulated immune system components in the experimental UC. The hUC-MSC-Exo inhibit inflammatory macrophages while promoting the anti-inflammatory activity of Th2 cells. Over-activated Th1/Th17 cells can be suppressed by hBM-MSC-Exo, hUC-MSC-Exo, and OE-MSC-Exo. The anti-inflammation activity of Treg cells can be improved by hBM-MSC-Exo, hAD-MSC-Exo, and OE-MSC-Exo. Over-expressed proinflammatory cytokines and hUC-MSC-Exo, hAD-MSC-Exo, and OE-MSC-Exo can reduce over-expressed proinflammatory cytokines while increasing the expression of pro-inflammatory cytokines

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Stem Cell Research & Therapy

ISSN: 1757-6512