Table 1 Preclinical findings of the MSCs therapy in the experimental IBD
Type of MSCs | Animal model of IBD | Infusion method | Outcome | References |
|---|---|---|---|---|
BM-MSCs | DSS-induced mouse model | IV injection | The increase in mucosal permeability The restoration of the damaged colon tissue The decrease in oxidative stress in colitis tissue | [15] |
DSS-induced mouse model | IV injection | The prevention and rapid recovery of weight loss The decrease in inflammatory infiltrates The protection on crypt structure damage | [16] | |
TNBS-induced guinea pig model | Enema infusion | The decrease in weight loss The decrease in flattening of the mucosa, hemorrhagic sites, loss of goblet cells, and altered presentation of the circular muscle layer The decrease in leukocyte infiltration to the myenteric ganglia | [17] | |
TNBS-induced mouse model | IP injection | The increase in the survival rate The decrease in intestinal inflammation The increase in the expression of anti-inflammatory cytokine IL10 The decrease in the secretion of proinflammatory cytokines TNF-α, IL-12, VEGF The repaired mucosal injury | [19] | |
AD-MSCs | TNBS-induced guinea pig model | Enema infusion | The decrease in weight loss The decrease in flattening of the mucosa, hemorrhagic sites, loss of goblet cells, and altered presentation of the circular muscle layer The decrease in leukocyte infiltration to the myenteric ganglia | [17] |
TNBS-induced rat model | IV injection | The decrease in the inflammation markers The amelioration of UC The repaired mucosal injury | [18] | |
TNBS-induced mouse model | IP injection | The increase in the survival rate The decrease in intestinal inflammation The increase in the expression of anti-inflammatory cytokine IL10 The decrease in the secretion of proinflammatory cytokines TNF-α, IL-12, VEGF The repaired mucosal injury | [19] | |
hUC-MSCs | DSS-induced mouse model | IP injection | The decrease in mucosal destruction and edema in the submucosa The decrease in colon inflammation The increase in the production of cytokine IL-10 in colon tissue The increase in Treg infiltration in the colon tissue The decrease in the production of proinflammatory cytokines IL-6, IFN-γ, and TNF-α in the colon tissue | [20] |
AM-MSCs | TNBS-induced rat model | IV injection | The improvement in the endoscopic and histological changes of colitis The decrease in the infiltration of neutrophils and macrophages The decrease in expression levels of TNF-α, CXCL1, and CCL2 | [21] |
TN-MSCs | DSS-induced mouse model | IP injection | The improvement in survival rates and body weight gain The increase in scores of disease activity index The normalization of the colon length The decrease in the expression levels of IL-1β and IL-6 | [22] |