Source of exosome | Therapeutic theory | Molecular target | References |
---|---|---|---|
UC-MSCs | ↓ Macrophage infiltration ↓ IL-1β, IL-6, IL-7, TNF-α, iNOS ↑ IL-10, IP-10 | Ubiquitin components Ubiquitin-associated molecules | |
↓ Macrophage pyroptosis | NLRP3 | [51] | |
↓ Th17 cells | TSG-6 | [52] | |
↑ Th2 cells | TSG-6 | [52] | |
AD-MSCs | ↑ Treg cells ↑ IL‐4, IL‐10, IL-13, TGF‐β ↓ IL-1β, IL-6, IL-12, IL-17, TNF-α, IFN‐γ | Not defined | |
BM-MSCs | ↑Treg cells ↓Th17 cells | Stat3 inhibition mediated by exosomal miR-125a and miR-125b | [70] |
OE-MSCs | ↑ Treg cells ↑ TGF-β, IL-10 ↓ Th1/Th17 cells ↓ IL-17, IFN-γ | Not defined | [71] |