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Table 2 Laboratory parameters in subjects with/without MSCs infusion on day 1, 7, 14, and 28

From: Safety of DW-MSC infusion in patients with low clinical risk COVID-19 infection: a randomized, double-blind, placebo-controlled trial

  High dose, n = 3 Low dose, n = 3 Placebo, n = 3
TH1 TH2 TH3 TL1 TL2 TL3 C1 C2 C3
White blood cell, /μL (normal range: 4–10 × 103/μL)
Day 1 5300 5900 7800 8200 7600 7600 4900 7500 5300
Day 7 4100 7200 7700 7400 8800 5100 4800 7300 7100
Day 14 5700 7700 5900 6800 9200 7900 5300 7000 8900
Day 28 5200 5000 7800 7700 7400 5800 5400 7100 6000
Lymphocyte, % (Normal range: 20–40%)
Day 1 31.5 30.3 43.3 34.2 24.3 28.5 38.2 34.8 44.4
Day 7 31.6 23.7 42.1 34.5 25.2 57.5 40.4 42.9 45.1
Day 14 37.9 27.7 42 44 24.3 39.8 46.3 58.3 24.7
Day 28 38.9 29.8 61.5 38.1 27.3 67.8 40.1 39 53.1
Erythrocyte sedimentation rate, mm/h (Normal range: Male < 10; Female < 20 mm/h)
Day 1 12 8 6 14 12 12 24 6 12
Day 7 14 11 2 15 26 15 17 5 12
Day 14 15 4 2 2 10 10 20 4 15
Day 28 11 2 2 30 16 6 15 4 13
CRP, mg/L (normal range: < 5 mg/L)
Day 1 0.8 5.2 0.6 0.7 0.2 12.7 0.4 0.8 1.8
Day 7 1.4 0.2 0.3 1.1 1 2.6 0.4 0.8 0.3
Day 14 0.1 0.3 1.9 1.1 3.5 0.5 0.5 0.6 0.2
Day 28 0.1 0.3 0.5 38.5 0.4 1 2.5 1.1 0.5
Fibrinogen, mg/dL (Normal range: 150–375 mg/dL)
Day 1 179 333 222 171 267.5 433.2 282.9 204.6 391.3
Day 7 192 241.6 169.2 181 319.1 319.1 282.9 212.8 288.5
Day 14 253.4 196.9 187.2 165.5 381.9 267.8 277.6 241.6 301.4
Day 28 224.8 232.3 192.6 476.1 249 240.4 253.4 207.5 295.3
IL-6, ng/L (Normal range: 0–16.4 ng/L)
Day 1 35.6 68.1 29 34.3 30.6 125.4 49.3 124.2 36.9
Day 7 10.7 30.6 44.3 26.9 29.4 34.4 64.3 38.1 0.6
Day 14 45.6 15.6 41.8 46.8 19.4 26.2 30.6 8.1 39.3
Day 28 26.9 16.4 23.1 58.1 61.8 20.6 13.2 11.3 18.1
TNF-α, ng/L (normal range: 0–29.4 ng/L)
Day 1 29.6 28.1 19 27.3 27.2 29.6 35.5 33 19.9
Day 7 19.9 23.1 12.6 22.3 24.8 13.4 30.5 27.2 10.9
Day 14 33 13.3 13.8 35.5 15.8 12.8 22.3 19.8 11.4
Day 28 20.7 107.3 19.8 28.1 69.9 16.6 11.8 16.8 19
IL-1β, ng/L (normal range: 0–5 ng/L)
Day 1 0.5 0.5 0.5 0.6 0.5 0.3 0.5 0 0.5
Day 7 0.8 0.3 0.2 1.1 0.5 0 0.1 0.3 0.1
Day 14 0.2 0.2 0 0.3 0.3 0.1 0.1 0.4 0.5
Day 28 0.4 0.1 0.8 0.1 0.1 1 0.1 0.3 0.9
IFN-γ, ng/L (normal range: < 8.1 ng/L)
Day 1 132 148 86 107 104 170 101 179 73
Day 7 86 170 25 123 104 107 86 195 58
Day 14 148 150 17 132 79 51 67 246 29
Day 28 123 30 79 132 19 58 51 33 51
  1. CRP C-reactive protein, IL-6 interleukin 6; TNF-α tumor necrosis factor-α, IL-1β Interleukin-1β, IFN-γ Interferon-γ