Table 2 Laboratory parameters in subjects with/without MSCs infusion on day 1, 7, 14, and 28
|  | High dose, n = 3 | Low dose, n = 3 | Placebo, n = 3 | ||||||
|---|---|---|---|---|---|---|---|---|---|
TH1 | TH2 | TH3 | TL1 | TL2 | TL3 | C1 | C2 | C3 | |
White blood cell, /μL (normal range: 4–10 × 103/μL) | |||||||||
Day 1 | 5300 | 5900 | 7800 | 8200 | 7600 | 7600 | 4900 | 7500 | 5300 |
Day 7 | 4100 | 7200 | 7700 | 7400 | 8800 | 5100 | 4800 | 7300 | 7100 |
Day 14 | 5700 | 7700 | 5900 | 6800 | 9200 | 7900 | 5300 | 7000 | 8900 |
Day 28 | 5200 | 5000 | 7800 | 7700 | 7400 | 5800 | 5400 | 7100 | 6000 |
Lymphocyte, % (Normal range: 20–40%) | |||||||||
Day 1 | 31.5 | 30.3 | 43.3 | 34.2 | 24.3 | 28.5 | 38.2 | 34.8 | 44.4 |
Day 7 | 31.6 | 23.7 | 42.1 | 34.5 | 25.2 | 57.5 | 40.4 | 42.9 | 45.1 |
Day 14 | 37.9 | 27.7 | 42 | 44 | 24.3 | 39.8 | 46.3 | 58.3 | 24.7 |
Day 28 | 38.9 | 29.8 | 61.5 | 38.1 | 27.3 | 67.8 | 40.1 | 39 | 53.1 |
Erythrocyte sedimentation rate, mm/h (Normal range: Male < 10; Female < 20 mm/h) | |||||||||
Day 1 | 12 | 8 | 6 | 14 | 12 | 12 | 24 | 6 | 12 |
Day 7 | 14 | 11 | 2 | 15 | 26 | 15 | 17 | 5 | 12 |
Day 14 | 15 | 4 | 2 | 2 | 10 | 10 | 20 | 4 | 15 |
Day 28 | 11 | 2 | 2 | 30 | 16 | 6 | 15 | 4 | 13 |
CRP, mg/L (normal range: < 5 mg/L) | |||||||||
Day 1 | 0.8 | 5.2 | 0.6 | 0.7 | 0.2 | 12.7 | 0.4 | 0.8 | 1.8 |
Day 7 | 1.4 | 0.2 | 0.3 | 1.1 | 1 | 2.6 | 0.4 | 0.8 | 0.3 |
Day 14 | 0.1 | 0.3 | 1.9 | 1.1 | 3.5 | 0.5 | 0.5 | 0.6 | 0.2 |
Day 28 | 0.1 | 0.3 | 0.5 | 38.5 | 0.4 | 1 | 2.5 | 1.1 | 0.5 |
Fibrinogen, mg/dL (Normal range: 150–375 mg/dL) | |||||||||
Day 1 | 179 | 333 | 222 | 171 | 267.5 | 433.2 | 282.9 | 204.6 | 391.3 |
Day 7 | 192 | 241.6 | 169.2 | 181 | 319.1 | 319.1 | 282.9 | 212.8 | 288.5 |
Day 14 | 253.4 | 196.9 | 187.2 | 165.5 | 381.9 | 267.8 | 277.6 | 241.6 | 301.4 |
Day 28 | 224.8 | 232.3 | 192.6 | 476.1 | 249 | 240.4 | 253.4 | 207.5 | 295.3 |
IL-6, ng/L (Normal range: 0–16.4 ng/L) | |||||||||
Day 1 | 35.6 | 68.1 | 29 | 34.3 | 30.6 | 125.4 | 49.3 | 124.2 | 36.9 |
Day 7 | 10.7 | 30.6 | 44.3 | 26.9 | 29.4 | 34.4 | 64.3 | 38.1 | 0.6 |
Day 14 | 45.6 | 15.6 | 41.8 | 46.8 | 19.4 | 26.2 | 30.6 | 8.1 | 39.3 |
Day 28 | 26.9 | 16.4 | 23.1 | 58.1 | 61.8 | 20.6 | 13.2 | 11.3 | 18.1 |
TNF-α, ng/L (normal range: 0–29.4 ng/L) | |||||||||
Day 1 | 29.6 | 28.1 | 19 | 27.3 | 27.2 | 29.6 | 35.5 | 33 | 19.9 |
Day 7 | 19.9 | 23.1 | 12.6 | 22.3 | 24.8 | 13.4 | 30.5 | 27.2 | 10.9 |
Day 14 | 33 | 13.3 | 13.8 | 35.5 | 15.8 | 12.8 | 22.3 | 19.8 | 11.4 |
Day 28 | 20.7 | 107.3 | 19.8 | 28.1 | 69.9 | 16.6 | 11.8 | 16.8 | 19 |
IL-1β, ng/L (normal range: 0–5 ng/L) | |||||||||
Day 1 | 0.5 | 0.5 | 0.5 | 0.6 | 0.5 | 0.3 | 0.5 | 0 | 0.5 |
Day 7 | 0.8 | 0.3 | 0.2 | 1.1 | 0.5 | 0 | 0.1 | 0.3 | 0.1 |
Day 14 | 0.2 | 0.2 | 0 | 0.3 | 0.3 | 0.1 | 0.1 | 0.4 | 0.5 |
Day 28 | 0.4 | 0.1 | 0.8 | 0.1 | 0.1 | 1 | 0.1 | 0.3 | 0.9 |
IFN-γ, ng/L (normal range: < 8.1 ng/L) | |||||||||
Day 1 | 132 | 148 | 86 | 107 | 104 | 170 | 101 | 179 | 73 |
Day 7 | 86 | 170 | 25 | 123 | 104 | 107 | 86 | 195 | 58 |
Day 14 | 148 | 150 | 17 | 132 | 79 | 51 | 67 | 246 | 29 |
Day 28 | 123 | 30 | 79 | 132 | 19 | 58 | 51 | 33 | 51 |