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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: Cell-free fat extract attenuates osteoarthritis via chondrocytes regeneration and macrophages immunomodulation

Fig. 3

Histological evaluation of structural changes and matrix deposition in cartilage and macrophage infiltration in synovium. A, G The longitudinal section of a rat joint was stained with HE. Quantitative analysis of HE staining score containing cartilage fibrosis and cartilage degeneration according to a 1–4 grading system. B, H Safranin-O fast green (S&F) staining of the longitudinal section of a rat bone. Quantitative analysis of S&F staining according to the OARSI standard. C GAG staining of cortical bone sections. D Anti-COL II staining of cortical bone sections. E, I Anti-CD206 staining of knee synovium. F, J Anti-CD68 staining of knee synovium. Scale bars are noted on the right bottom corner of each picture. Data represent the mean ± SD (n = 6 per group). *p < 0.05; **p < 0.01; ns, no significant difference between groups

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