Fig. 5

HIRA complex members regulate TE transcription genome-widely. a–c Scatter diagrams show transcriptome analysis of TE expression change after the depletion of Hira (a) or Ubn2 (b) or Ubn1 (c) by shRNAs. TE transcript results were used to plot these diagrams. Colored dots indicate retroelements with significant expression change (Wald test, FDR adjusted P value < 0.05). d Heatmap of RNA-Seq expression Z-scores computed for genes that are differentially expressed in Hira, Ubn1, and Ubn2 depletion by shRNAs in ESCs versus control ESCs. Upregulated and downregulated genes are represented with red and blue colors respectively. Each column corresponds to a sample and each row corresponds to a specific gene