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Table 3 Mesenchymal stromal cells (MSCs) derived molecules (e.g., exosome) in liver failure preclinical models, especially acute liver failure (ALF)

From: Mesenchymal stromal cells (MSCs) and their exosome in acute liver failure (ALF): a comprehensive review

Sources Model Intervention Result (ref)
Umbilical cord Mice MSCs-exosome GPX1 enriched exosomes diminished oxidative stress and also apoptosis [105]
Placenta Rat MSCs-exosome CRP enriched exosome provoked angiogenesis by up-regulation of Wnt signaling axis [149]
Bone marrow Rat MSCs-exosome Stimulation of hepatoprotective impacts by exosome-rich fractionated secretome [150]
Bone marrow Mice MSCs-exosome Suppression of NLRP3 in macrophage and thereby reducing ALF by TNF-ɑ pretreated exosome [107]
Menstrual blood Mice MSCs-exosome Liver function recovery, improved survival rates, and suppressed hepatocellular apoptosis [151]
Umbilical cord Mice MSCs-extracellular vesicles Inhibition of T cell activation in liver tissue following reserve of CD154 expression [147]
Bone marrow Mice MSCs-conditioned medium Promoting hepatocyte proliferation, inhibition of their apoptosis, hindrance of the infiltration of macrophages, improving Th2/Th1 ratio, and enabling hepatic stellate cell (HSC) loss [157]
Bone marrow Rat MSCs-conditioned medium Marked attenuation of panlobular immune cells infiltrates and also hepatocellular apoptosis [210]
ESCs-MSCs Mice MSCs-conditioned medium Supporting hepatocytes growth by VEGF enriched conditioned medium [156]
Bone marrow Mice MSCs-exosome Attenuation of liver inflammation by exosomal miR-20a-5p/intracellular CXCL8 axis [146]
Bone marrow Rat MSCs-conditioned medium Reduced hepatocyte apoptosis [154]
Bone marrow Rat MSCs-conditioned medium Improving the hepatoprotective impacts of the conditioned medium by SMGO potently elicited through inhibition of inflammation and loss of hepatocytes [155]
Amniotic fluid Mice MSCs-conditioned medium Hepatic progenitor-like (HPL)-CM showed superiority over amniotic fluid-MSCs in terms of liver recovery [158]
  1. Silica magnetic graphene oxide (SMGO), NLR family pyrin domain containing 3 (NLRP3), Tumor necrosis factor-ɑ (TNF-ɑ), T helper 1/2 (Th1/2), Vascular endothelial growth factor (VEGF), Interleukin 8 (IL-8 or CXCL8), Conditioned medium (CM), Embryonic stem cells (ESCs), Glutathione peroxidase1 (GPX1), C-reactive protein (CRP)
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Stem Cell Research & Therapy

ISSN: 1757-6512