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Table 4 Clinical trials based on MSCs-based therapies in liver diseases (e.g., ALF)

From: Mesenchymal stromal cells (MSCs) and their exosome in acute liver failure (ALF): a comprehensive review

Condition Cell Source Participant no Main results (ref)
Primary biliary cirrhosis Allogeneic UC 7 Robust attenuation in serum ALP and GGT levels [168]
Liver failure Allogeneic UC 43 Enchantment in the survival rates without side effects [162]
HBV-induced liver cirrhosis Autologous BM 56 Improving the Treg/Th17 cell ration [171]
Liver cirrhosis Autologous BM 25 Removing the HCV RNA caused by transplanted MSCs-mediated paracrine effect [211]
Decompensated liver cirrhosis Autologous BM 4 Improved the quality of life without serious side effects [167]
Alcoholic liver cirrhosis Autologous BM 12 No side effects in concomitant with histological and quantitative amelioration [212]
HCV-induced liver cirrhosis Autologous BM 40 Normalization of liver enzymes levels in association with restoration in liver function [213]
Liver cirrhosis Autologous BM 8 Improved liver function evidenced by enhanced serum albumin and reduced total bilirubin[172]
Liver failure Autologous BM-derived hepatocyte 40 Improvement in ascites, lower limb edema as well as serum albumin levels [163]
Decompensated liver cirrhosis Allogeneic UC 45 Improved level function documented with enhanced serum albumin levels and reduced total bilirubin levels [180]
HCV-induced liver cirrhosis Autologous BM 20 Amelioration of liver function in Egyptian patients [170]
HCV-induced liver cirrhosis Autologous BM 25 Partial rescue in liver function [169]
Decompensated liver cirrhosis Autologous BM 27 No significant beneficial effect [174]
Liver failure Allogeneic BM 110 Improved overall survival and also reduced incidence of severe infections [164]
Liver cirrhosis Allogeneic (UC, UCB, BM) 26 Stromal cell injection by peripheral vein was safe and partially effective [173]
HBV-induced liver cirrhosis Allogeneic UC 40 Enhanced IL-10 levels and also reduced IL-6 and TNF-ɑ levels [214]
Ischemic-type biliary lesions following liver transplantation Allogeneic UC 12 Stem cell injection was safe and elicited favorable short-term outcomes [215]
Alcoholic liver cirrhosis Autologous BM 72 Ameliorated histologic fibrosis and liver normal activity [216]
Liver allograft rejection Allogeneic UC 27 Improved Treg/Th17 cell ratio [217]
Liver allograft rejection Allogeneic BM 10 No side effect [218]
  1. Gamma-glutamyl transferase (GGT), Alkaline phosphatase (ALP), Bone marrow (BM), Umbilical cord (UC), Umbilical cord blood (UCB), Adipose tissue (AT), Hepatitis C virus (HCV), Hepatitis B virus (HBV)