Table 2 Downregulated genes in EYS-RP-derived photoreceptor-like cells
GeneSymbol | GeneName | Pt #1 non-induced (1) | Pt #1 induced (1) | N #3 non-induced (1) | N #3 induced (1) | Pt #1 non-induced (2) | Pt #1 induced (2) | N #2 non-induced (2) | N #2 induced (2) |
|---|---|---|---|---|---|---|---|---|---|
LZTS1 | Leucine zipper, putative tumor suppressor 1 | 3.24 | 5.45 | 5.39 | 9.43 | 2.81 | 5.24 | 2.98 | 6.85 |
SST | Somatostatin | 1.00 | 4.40 | 1.11 | 8.27 | 2.89 | 4.29 | 2.27 | 8.05 |
TNNC1 | Troponin C type 1 (slow) | 3.42 | 4.27 | 3.68 | 7.76 | 2.70 | 4.39 | 2.98 | 7.01 |
FOXS1 | Forkhead box S1 | 1.66 | 3.84 | 1.76 | 7.07 | 1.07 | 4.16 | 1.94 | 6.00 |
ANO2 | Anoctamin 2, calcium activated chloride channel | 1.48 | 4.51 | 2.48 | 7.60 | 1.78 | 4.58 | 1.86 | 6.31 |
HES6 | Hes family bHLH transcription factor 6 | 2.03 | 4.08 | 2.28 | 7.15 | 3.11 | 5.29 | 3.23 | 6.47 |
NLRP12 | NLR family, pyrin domain containing 12 | 0.79 | 3.12 | 0.93 | 6.10 | 1.19 | 3.17 | 0.29 | 6.42 |
KRT18 | Keratin 18, type I | 1.63 | 4.02 | 4.34 | 6.90 | 2.40 | 3.67 | 3.05 | 6.57 |
HES6 | Hes family bHLH transcription factor 6 | 7.15 | 10.31 | 7.33 | 13.15 | 7.54 | 10.83 | 8.04 | 12.32 |
CKMT1A | Creatine kinase, mitochondrial 1A | 1.11 | 6.16 | 1.17 | 8.82 | 1.67 | 5.82 | 1.42 | 7.10 |
3.06 | 3.93 | 3.94 | 6.52 | 2.75 | 3.79 | 3.05 | 5.96 | ||
DIRAS3 | DIRAS family, GTP-binding RAS-like 3 | 4.08 | 7.61 | 5.35 | 10.11 | 4.10 | 8.07 | 4.62 | 9.89 |
PDLIM3 | PDZ and LIM domain 3 | 2.93 | 5.31 | 4.28 | 7.78 | 0.59 | 4.16 | 0.50 | 5.70 |
C8orf46 | Chromosome 8 open reading frame 46 | 2.37 | 5.04 | 2.69 | 7.47 | 1.08 | 5.38 | 1.02 | 7.36 |
ASMT | Acetylserotonin O-methyltransferase | 3.27 | 3.88 | 3.05 | 6.28 | 1.92 | 4.36 | 1.47 | 7.99 |
COL4A1 | Collagen, type IV, alpha 1 | 5.41 | 7.26 | 6.24 | 9.66 | 6.17 | 7.64 | 6.19 | 9.59 |
LYPD1 | LY6/PLAUR domain containing 1 | 4.31 | 5.37 | 5.84 | 7.73 | 4.45 | 5.13 | 3.44 | 7.71 |
C2CD4A | C2 calcium-dependent domain containing 4A | 0.52 | 6.08 | 0.51 | 8.36 | 1.21 | 5.85 | 2.08 | 7.60 |
NRL | Neural retina leucine zipper | 3.15 | 8.05 | 2.60 | 10.31 | 2.86 | 8.76 | 1.91 | 10.17 |
COL4A2 | Collagen, type IV, alpha 2 | 8.89 | 10.43 | 9.70 | 12.66 | 9.76 | 10.68 | 9.49 | 12.02 |
NRL | Neural retina leucine zipper | 4.04 | 8.84 | 4.12 | 11.06 | 3.83 | 9.51 | 3.46 | 11.02 |
LINC00463 | Long intergenic non-protein coding RNA 463 | 0.84 | 4.19 | 0.96 | 6.34 | 0.85 | 4.35 | 0.45 | 6.09 |
ADRA2A | Adrenoceptor alpha 2A | 4.64 | 7.20 | 4.12 | 9.27 | 4.29 | 7.40 | 3.74 | 8.79 |
NTRK3 | Neurotrophic tyrosine kinase, receptor, type 3 | 2.36 | 2.14 | 0.59 | 4.06 | 1.04 | 3.06 | 1.54 | 5.67 |
NGFR | Nerve growth factor receptor | 0.55 | 4.51 | 0.60 | 6.43 | 0.55 | 4.91 | 0.50 | 7.60 |
MPPED2 | Metallophosphoesterase domain containing 2 | 0.65 | 5.29 | 0.82 | 7.18 | 0.37 | 5.64 | 0.33 | 7.84 |
AMER2 | APC membrane recruitment protein 2 | 0.78 | 8.01 | 0.80 | 9.76 | 0.68 | 7.97 | 1.49 | 9.80 |
CTSH | Cathepsin H | 6.82 | 7.64 | 7.24 | 9.36 | 6.46 | 7.30 | 6.02 | 9.51 |
PDZD2 | PDZ domain containing 2 | 2.19 | 6.21 | 2.38 | 7.92 | 0.39 | 6.33 | 0.99 | 8.45 |
TCF15 | Transcription factor 15 (basic helix-loop-helix) | 6.12 | 5.76 | 6.57 | 7.45 | 5.49 | 5.57 | 5.53 | 6.92 |
F2R | Coagulation factor II (thrombin) receptor | 2.38 | 4.05 | 2.99 | 5.68 | 3.10 | 4.80 | 3.53 | 6.61 |
GRAMD1C | GRAM domain containing 1C | 5.88 | 7.06 | 6.06 | 8.62 | 4.88 | 7.00 | 4.46 | 8.98 |
GPX3 | Glutathione peroxidase 3 (plasma) | 4.82 | 8.34 | 5.16 | 9.87 | 4.60 | 8.44 | 3.98 | 10.67 |
BEGAIN | Brain-enriched guanylate kinase-associated | 4.33 | 4.39 | 5.47 | 5.92 | 4.45 | 4.63 | 4.82 | 6.59 |
TMEM176A | Transmembrane protein 176A | 3.66 | 9.80 | 3.69 | 11.31 | 4.13 | 10.15 | 4.75 | 11.75 |
A2M | Alpha-2-macroglobulin | 7.24 | 5.96 | 8.35 | 7.45 | 8.67 | 6.78 | 9.16 | 8.00 |
TMSB15A | Thymosin beta 15a | 4.54 | 4.05 | 5.37 | 5.51 | 3.62 | 4.14 | 4.51 | 5.85 |
GPRC5B | G protein-coupled receptor, class C, group 5, member B | 3.92 | 7.32 | 3.45 | 8.77 | 4.13 | 7.61 | 3.75 | 10.06 |
IMPG1 | Interphotoreceptor matrix proteoglycan 1 | 0.60 | 4.33 | 0.56 | 5.74 | 0.54 | 3.93 | 0.43 | 6.05 |
PLEKHB1 | Pleckstrin homology domain containing, family B (evectins) member 1 | 4.54 | 7.65 | 4.43 | 9.05 | 4.63 | 7.46 | 3.97 | 9.67 |
SYPL2 | Synaptophysin-like 2 | 7.12 | 7.76 | 6.99 | 9.15 | 6.21 | 7.72 | 5.26 | 9.92 |
SLC16A3 | Solute carrier family 16 (monocarboxylate transporter), member 3 | 11.28 | 11.44 | 13.32 | 12.77 | 13.11 | 11.60 | 14.03 | 12.88 |
CBX2 | Chromobox homolog 2 | 2.08 | 5.02 | 1.71 | 6.21 | 3.61 | 5.17 | 3.52 | 6.36 |
CCDC13 | Coiled-coil domain containing 13 | 2.07 | 6.52 | 2.39 | 7.66 | 1.83 | 7.00 | 1.92 | 8.75 |
MECOM | MDS1 and EVI1 complex locus | 4.27 | 3.93 | 4.27 | 5.06 | 3.67 | 3.40 | 4.43 | 5.65 |
RXRG | Retinoid X receptor, gamma | 0.69 | 6.30 | 0.72 | 7.40 | 0.42 | 6.87 | 0.39 | 8.48 |
CCDC181 | Coiled-coil domain containing 181 | 3.07 | 8.39 | 3.76 | 9.48 | 3.08 | 8.35 | 3.84 | 9.70 |
GNB3 | Guanine nucleotide binding protein (G protein), beta polypeptide 3 | 3.90 | 6.99 | 3.99 | 8.06 | 3.62 | 7.18 | 4.42 | 8.70 |
OXTR | Oxytocin receptor | 6.26 | 7.83 | 5.87 | 8.86 | 4.82 | 7.44 | 4.35 | 9.65 |
4.79 | 4.45 | 5.12 | 5.46 | 3.95 | 4.72 | 4.92 | 6.30 |