Fig. 9From: Human primitive mesenchymal stem cell-derived retinal progenitor cells improved neuroprotection, neurogenesis, and vision in rd12 mouse model of retinitis pigmentosaGO analysis of top mouse DEGs in rd12 mice retina transplanted with cells and validation by qRT-PCR. Enrichr and PANTHER analyses of DEGs were performed with p < 0.05 using DESeq2 after 8 week cell transplantation. A–C GO term enrichment analysis of upregulated DEGs associated with biological processes, molecular function, and cellular component, respectively, and the x-axis represents the combined score generated by Enrichr (**p ≤ 0.01). D, E Protein classes and pathways upregulated in rd12 + pMSCs and rd12 + RPCs, as determined by PANTHER analysis. The x-axis represents the number of genes associated with each category. F, G Expression of anti-inflammatory and neurogenesis genes in rd12, rd12 + pMSCs and rd12 + RPCs and expression ± SEM normalized to rd12 and r12 + pMSCs, respectively, as determined by qRT–PCR. Symbols, #, & and $ indicate significant difference at p ≤ 0.01 between all experimental conditions: rd12, rd12 + pMSCs and rd12 + RPCs, respectivelyBack to article page