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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: MFN2 knockdown promotes osteogenic differentiation of iPSC-MSCs through aerobic glycolysis mediated by the Wnt/β-catenin signaling pathway

Fig. 3

MFN2 knockdown enhances glycolysis of iPSC-MSCs. A–B The relative basal glycolysis and glycolytic capacity of WT, MFN2-KD, and MFN2-OE iPSC-MSCs. C, F qRT-PCR analysis of glycolytic enzymes in WT, MFN2-KD, and MFN2-OE iPSC-MSCs. D, G Relative activity of glycolytic enzymes in WT, MFN2-KD, and MFN2-OE iPSC-MSCs. E, H Lactic acid levels of WT, MFN2-KD, and MFN2-OE iPSC-MSCs. I–J The relative basal and maximal respiration of WT, MFN2-KD, and MFN2-OE iPSC-MSCs. NC: negative control. ns, no significant. Data are expressed as mean ± SD, *P < 0.05, **P < 0.01, ***P < 0.001

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Stem Cell Research & Therapy

ISSN: 1757-6512