Fig. 9From: MFN2 knockdown promotes osteogenic differentiation of iPSC-MSCs through aerobic glycolysis mediated by the Wnt/β-catenin signaling pathwayMFN2 knockdown promotes osteogenic differentiation through aerobic glycolysis via the Wnt/β-catenin signaling pathway in PDLSCs. A–B qRT-PCR analysis of osteogenic differentiation markers in WT, MFN2-KD, MFN2-OE PDLSCs, and cells treated with XAV-939 and SKL2001 after osteogenic differentiation. C–D Western blot analysis of osteogenic differentiation markers in WT, MFN2-KD, MFN2-OE PDLSCs, and cells treated with XAV-939 and SKL2001 after osteogenic differentiation. E Alizarin red staining of WT, MFN2-KD, MFN2-OE PDLSCs, and cells treated with XAV-939 and SKL2001 after osteogenic differentiation. IM, osteogenic induction medium. ns, no significant. Data are expressed as mean ± SD, *P < 0.05, **P < 0.01, ***P < 0.001Back to article page