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Fig. 9 | Stem Cell Research & Therapy

Fig. 9

From: MFN2 knockdown promotes osteogenic differentiation of iPSC-MSCs through aerobic glycolysis mediated by the Wnt/β-catenin signaling pathway

Fig. 9

MFN2 knockdown promotes osteogenic differentiation through aerobic glycolysis via the Wnt/β-catenin signaling pathway in PDLSCs. A–B qRT-PCR analysis of osteogenic differentiation markers in WT, MFN2-KD, MFN2-OE PDLSCs, and cells treated with XAV-939 and SKL2001 after osteogenic differentiation. C–D Western blot analysis of osteogenic differentiation markers in WT, MFN2-KD, MFN2-OE PDLSCs, and cells treated with XAV-939 and SKL2001 after osteogenic differentiation. E Alizarin red staining of WT, MFN2-KD, MFN2-OE PDLSCs, and cells treated with XAV-939 and SKL2001 after osteogenic differentiation. IM, osteogenic induction medium. ns, no significant. Data are expressed as mean ± SD, *P < 0.05, **P < 0.01, ***P < 0.001

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Stem Cell Research & Therapy

ISSN: 1757-6512