Fig. 7

Intracranial injection of AAV-BCAS2 can rescue neurogenesis in hippocampus of BCAS2 cKO mice. A Diagram of AAV intracranial injection strategy on days 0 and 11 for BrdU intraperitoneal administration for three consecutive days, and day 14 for analysis. B Representative images of BrdU⁺Sox2⁺ cells. Arrows: BrdU⁺Sox2⁺ cells. Scale bar: 100 μm. Quantification of Ba BrdU⁺ cells and Bb proportion of Sox2⁺BrdU⁺/Sox2⁺ cells in SGZ. Data are mean ± SEM by Student’s t test. C Ki67⁺ cells. Quantification of Ca Ki67⁺ and Cb GFP⁺Ki67⁺/GFP⁺ cells. D DCX⁺ immature neurons in hippocampal dentate gyrus. Quantification of Da DCX⁺ and Db GFP⁺DCX⁺/GFP⁺ cells. Data are mean ± SEM by Student’s t test, *P < 0.05; **P < 0.01; ***P < 0.005