Fig. 8

Intracranial injection of AAV-BCAS2 can restore β-catenin level in hippocampus of BCAS2 cKO mice. A Western blot analysis of exogenous BCAS2-GFP and endogenous BCAS2 protein levels in the cortex and hippocampus of cKO-BCAS2 mice after AAV-BCAS2 and AAV-GFP treatment. The endogenous BCAS2 level was decreased in cKO mice as described previously [5]. Quantification of β-catenin protein level in B hippocampus and C cortex. D Working model of BCAS2 inducing adult neurogenesis via β-catenin for autonomous (stem cells and immature neurons) and/or non-autonomous effects (astrocytes and interneurons). Data are mean ± SEM. *P < 0.05, ns not significant