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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: Menstrual blood-derived mesenchymal stromal cells efficiently ameliorate experimental autoimmune encephalomyelitis by inhibiting T cell activation in mice

Fig. 5

MB-MSC transplantation into the peritoneum reduced EAE disease severity as effective as intravenous transplantation. a P4 MB-MSCs were labelled with CFSE and transplanted by either i.v. (MB-MSC_i.v.) or i.p. (MB-MSC_i.p.) injection 6 days after EAE induction. 4, 24, 72 h and 7 days after transplantation, MB-MSCs were detected in the lungs by analyzing CFSE and human CD29 staining. Representative FACS plots demonstrate the presence of MB-MSCs in lung after i.v. injection but not i.p. injection. n = 2 per group and time point. b EAE severity was monitored daily in mice that received MB-MSC i.v. or i.p. or were left untreated. c–e Maximal disease scores, cumulative disease scores, and disease incidence rate were determined and compared. Pool of four experiments. n = 20, 21, or 24 per group

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