Skip to main content
Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: Every road leads to Rome: therapeutic effect and mechanism of the extracellular vesicles of human embryonic stem cell-derived immune and matrix regulatory cells administered to mouse models of pulmonary fibrosis through different routes

Fig. 6

Analysis of transcriptome changes in BLM-induced pulmonary fibrosis and the EV treatment groups through IT or IV routes. a Principal coordinates analysis (PCA) of transcriptome differences among the Control, BLM, IT_EVs and IV_EVs groups. Colors and shapes indicate different groups. Ellipses indicate the 95% confidence interval. b Comparison of the slopes among BLM, control groups and different pathways of EVs delivery groups. c Differentially expressed mRNAs among the four groups. d Gene expression heatmap across different groups for the DEGs. Heatmap colors indicate normalized gene expression ranging from high (red) to low (blue). e The bubble chart of GO enrichment of pairwise differentially expressed genes. The color of bubbles indicates the P-value, and the radius of bubbles is the gene ratio. Gene ratio, the percentage of DEGs in the enriched gene set

Back to article page

Stem Cell Research & Therapy

ISSN: 1757-6512