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Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: NFκB inhibition to lift the mechano-competence of mesenchymal stromal cell-derived neocartilage toward articular chondrocyte levels

Fig. 2

Load-induced regulation of mechano-sensitive gene expression. RNA was isolated at termination of loading from compressed and free-swelling control samples and mRNA levels were determined by qPCR. Gene expression was normalized to the mean expression of reference genes HNRPH1 and CPSF6. A AC-derived engineered cartilage on day 21 (n = 5 donors), B MSC-derived engineered cartilage on day 21 (n = 8 donors), C AC-derived engineered cartilage on day 35 (n = 4 donors), D MSC-derived engineered cartilage on day 35 (n = 6 donors). Data are shown as mean ± SD. T-test, *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001 compressed vs. free-swelling controls

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