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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: MicroRNA-146a-5p-modified human umbilical cord mesenchymal stem cells enhance protection against diabetic nephropathy in rats through facilitating M2 macrophage polarization

Fig. 4

High-throughput sequencing analysis of miRNA profile in the DN kidney and UC-MSCs. miRNAs high-throughput sequencing was performed to identify specific miRNAs which were abnormal expression in the DN kidney and abundant in UC-MSCs derived exosomes. a The heatmap of down- or up-regulated miRNAs identified by RNA high-throughput sequencing in the control and DN kidney, n = 3 rats/group. b The heatmap of down- or up-regulated miRNAs identified by high-throughput sequencing in the HEK293T- and UC-MSC-derived exosomes, n = 3 samples/group. c The expression of miR-146a-5p in the kidney from DN rats with or without UC-MSC administration, n = 5–8 rats/group. d The expression of miR-146a-5p in UC-MSCs with or without LPS(100 ng/ml)/IFN-γ(30 ng/ml) stimulation. e Correlation analysis of miR-146a-5p and serum Cre in rats. f Correlation analysis of miR-146a-5p and serum BUN in rats, n = 20 rats. Data presented as mean ± SD of individuals included in each group. Results in vitro are representative of three independent experiments. *P < 0.05, **P < 0.01

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